Isolation of phospholipase A isoenzymes from Naja naja venom and their action on membrane-bound enzymes.
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منابع مشابه
Phospholipase A of Snake Venoms I. ISOLATION AND MOLECULAR PROPERTIES OF ISOENZYMES FROM NAJA NAJA AND VIPERA
A combination of narrow range isoelectric focusing, electrophoresis on polyacrylamide gel, and gel exclusion on Sephadex reveals the presence of at least 9, possibly 11 isoenzymes of phospholipase A in Naja naja (cobra) venom. Their isoelectric points range from pH 4.60 to 5.66 and their molecular weights from 8,500 to 20,200. The most abundant form (isoelectric point = pH 4.95) has been isolat...
متن کاملPhospholipase A of snake venoms. I. Isolation and molecular properties of isoenzymes from Naja naja and Vipera russellii venoms.
A combination of narrow range isoelectric focusing, electrophoresis on polyacrylamide gel, and gel exclusion on Sephadex reveals the presence of at least 9, possibly 11 isoenzymes of phospholipase A in Naja naja (cobra) venom. Their isoelectric points range from pH 4.60 to 5.66 and their molecular weights from 8,500 to 20,200. The most abundant form (isoelectric point = pH 4.95) has been isolat...
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Snake venom is a complex mixture of proteins, peptides, enzymes, carbohydrates, and minerals. They contain a variety of chemicals with pharmacological and toxicological properties. The innate immune system is the first line of defense against toxins and microbes. Antibacterial and anticancer proteins produced by snake venom have recently attracted significant attention due to their relevance to...
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Treatment of the electron transport membrane fraction of Rhodospirillum rubrum with phospholipase A from the venom of Naja Naja resulted in a stimulation of NADHand succinate-cytochrome c-reductase of the electron transfer chain. The mechanism of this stimulation appears to be identical with that found in the presence of the anionic detergent deoxycholate. At the same time the NADH oxidase syst...
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The resistance of bacteria against the use of conventional antibiotics has become a serious threat to public health and considering the associated side effect with antibiotics; new strategies to find and develop new molecules with novel modes of action has received grate attention in recent years. In this study, when the antibacterial potential of an acidic protein-NN-XIb-PLA2 (Naja naja venom ...
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عنوان ژورنال:
- Biochemical and biophysical research communications
دوره 33 6 شماره
صفحات -
تاریخ انتشار 1968